Conflicts of Interest on Stilts - or is it on Steroids?

Conflicts of Interest on Stilts - or is it Steroids? - Read George Monbiot's Guardian article. "Democracy itself is being undermined by publicly funded agencies crawling with conflicts of interest and devoid of scrutiny" I urge you to read the whole of this excellent article about how undue power is increasingly being accorded to Big Pharma and other industrial giants, while ordinary voters and other taxpayers go unrepresented on these quangos.

And here is some of what Dr Rath has to say about this: "At the time of writing, the Board of Britain’s Medicines and Healthcare Products Regulatory Agency (MHRA) contains retired senior executives from drug companies AstraZeneca and Merck Sharp & Dohme. Similarly, its Executive Board contains a former employee of Glaxo, DuPont and DuPont Pharmaceuticals who is currently an employee of Bristol-Myers Squibb; a former employee of Glaxo Wellcome and GlaxoSmithKline; and a former employee of SmithKline Beecham. Continuing this pattern, the council members on the country’s Medical Research Council (MRC) include representatives of Sanofi Pasteur and Pfizer, whilst its Global Health Group and Translational Research Group both have members from GlaxoSmithKline."

AstraZeneca Pays to settle 17,500 of the outstanding Seroquel Suits

AstraZeneca is moving closer to resolving the large number of lawsuits filed in the US over claims that the risks of its Seroquel antipsychotic were not properly disclosed. In this disclosure, AstraZeneca has agreed to pay about $198 million to settle 17,500, or roughly two-thirds of the outstanding lawsuits, according to a statement.
Read article at pharmalot.com

AstraZenica, its drug, Seroquel, its illegal marketing of antipsychotic drugs,

and its misleading of doctors and patients, and the serious harm Seroquel does to the unfortunate patients/victims who take or have taken it, reported here by the New York Times.

I urge you to read the article in full. It contains a resumé of other pharmaceutical companies who have similarly poisoned the people who have taken their dangerous antipsychotic and painkiller junk. Some of the damaged people are children, their lives and health now permanently blighted by massive weight gain, diabetes and other attendant ill-health. Some victims have actually died from the adverse effects.

Yes, the evil pharmaceutical industry pays out huge sums of money in a sort of system of fines, though these huge sums are insignificant set against their colossal profits, but they don't seem to go to prison for these crimes against humanity, including what many would regard as torture and murder, do they? Why? Why don't they go to prison? They knowingly lie about the results of drug trials. They knowingly supply products they know will do grave harm. - Why does the judicial system not protect the citizens? Should the members of the judiciary be held to account? Should they themselves go to prison?

In a fierce and deadly irony, I see that on the same webpage as the report to which I refer, there is an advertisement to recruit volunteers to take part in drug trials! - Not me, guv!

If you, or anyone you know - maybe one of those poor, damaged children - gained weight from taking any of these ghastly drugs, or gained weight from taking any other prescription drugs, please be aware that that weight gain can be reduced by cutting down on salt and salty food. - It makes a great difference, believe me. Please tell these victims. Do not have it on your conscience that you failed to tell them about this safe, fast, effective way to lose excess weight and improve their health and happiness. Don't pass by on the other side and leave them to suffer needlessly.

See Sodium in foods.

Lose weight

vulnerable groups

Fat Retention

Radio 4's File on 4 tonight deals with how AstraZeneca 'suppressed' Seroquel drug test data re massive weight gain and diabetes side-effects

Radio 4's File on 4 tonight (26/01/2010) deals with how AstraZeneca 'suppressed' Seroquel drug test data about its side-effects of massive weight gain and diabetes. See article on BBC News. "The marketing team sued over a drug's alleged side effects tried to suppress key data, an ex-employee has claimed. Seroquel's former UK medical adviser told the BBC he was pressured to approve promotional material which said weight gain was not an issue."

The British Medical Journal editor, Dr Fiona Godlee, sensibly urges that the medicine licensing system be reviewed. She says the pharmaceutical industry should no longer provide the evaluations of its own drugs for the licensing body to consider.

See also File on 4 itself: "A British drug company is being sued by more than 15,000 people in the United States who claim its bestselling antipsychotic drug caused severe weight gain, diabetes and other serious medical conditions. Ann Alexander investigates concerns about the way it was marketed and asks how much the public should be told about the drugs they take."

Actually there are dozens of commonly prescribed drugs that have these side-effects and these are obviously a major cause of the continuing rise in the incidence and severity of obesity and type 2 diabetes and a host of other degenerative illnesses that are co-morbidities of obesity. The drugs include cortico-steroids, HRT and other medications containing oestrogen - like some birth control medication (contraceptives), tricyclic anti-depressants, especially amitriptyline, some SSRI anti-depressants, anti-psychotics (notoriously Zyprexa,aka olanzapine), some anti-epileptics/anticonvulsants, e.g. Epilim (sodium valproate). This is by no means an exhaustive list. See my webpage about steroids and HRT et al.

So the NHS (and all other purchasers of pharmaceutical drugs the world over), as well as paying for the drugs that its doctors prescribe, incurs the astronomical costs of the vast spectrum of disabling chronic health problems they cause. - ALL of this avoidable ill-health and suffering results from the primary adverse side-effect, which is sodium retention, and all of the innocent patients who are its victims become sensitive to salt/sodium, and should have been warned strictly to avoid salt and salty food while taking the medication, because for them, salt intake causes them weight gain. I have been researching this subject intensively for well over ten years now, and I have not heard of even one doctor who gives and stresses this vital message to his/her victims/patients. Inadequate knowledge of drug side-effects is lamentably widespread in the medical profession. Read my Mensa article on Obesity and the Salt Connection.

Lose weight, reduce your risk of most cancers, high blood pressure, type 2 diabetes, heart disease, heart attack, vascular dementia, stroke, osteopenia, osteoporosis, osteomalacia, hypercholesterolaemia, depression, liver and kidney problems, boost your lung function and improve your health in many other ways without drugs, hunger or expense by eating less salt! - Try it!

See my website www.wildeaboutsteroids.co.uk
The site does not sell anything and has no banners or sponsors or adverts - just helpful information.

Sodium in foods

Fat retention and fat excretion: the importance of getting enough calcium.

Charity guide criticised for not declaring GM interests

Sense About Science pamphlet failed to list contributors' links with industry. Zoë Corbyn reports
A charity has come under fire for failing to declare all industry affiliations of the experts it enlisted to compile a booklet explaining genetic modification to the public. The pamphlet was produced by Sense About Science (SAS), a charity that claims to promote scientific reasoning in public discussions. According to anti-genetic modification campaigners and academics, it failed to mention links between some of the experts who wrote the booklet and GM firms. For example, the guide's biography of Vivian Moses, emeritus professor of microbiology at Queen Mary, University of London, and visiting professor of biotechnology at King's College London, does not mention that he is also chairman of CropGen, a GM lobby group that receives funding from the biotechnology industry.
Read article in The Times (UK)
Comment: In addition to its links with the GM industry, Sense About Science also has links with the pharmaceutical industry. In the past year, it has received financial contributions from AstraZeneca plc, the Royal Pharmaceutical Society of Great Britain, and a number of large medical charities who themselves have received financial contributions from drug companies.

Patients should be given facts about pharmaceutical drugs

Pharmaceutical companies spend millions each year to market drugs to doctors and potential patients. That makes it all the more outrageous that AstraZeneca is asking an Orlando court to keep information about the performance of its lucrative antipsychotic drug Seroquel secret. The company is claiming public safety, saying it shouldn't be required to release information about the drug that could cause a panic among "a vulnerable patient population" that might stop taking the drug without a doctor's oversight. But the real public safety issue is one of public health and whether the company hid findings that Seroquel causes weight gain and diabetes. The legal system must put public health — and a patient's right to know — above a company's interest in secrecy.
Read editorial in the St. Petersburg Times (Florida/USA)

Lose weight, by eating less salt! - Try it! - You will feel so much better!

Swedish Officials Investigating Nobel Prize Board

Swedish Officials Investigating Nobel Prize Board - news published
Friday, December 12, 2008 7:18 PM:

The Nobel Prize Committee is facing criminal investigation of bribery and corruption after allegedly taking huge payments from a pharmaceutical company that directly benefits from the work of this year's Nobel Prize winner in medicine. The astonishing scandal, being reported in the European trade press and conspicuously absent from Sweden's major daily newspapers, surfaced just days before the internationally renowned awards were presented in Stockholm on Wednesday. According to Swedish trade journal Dagens Medicin, two Nobel-affiliated corporations – Nobel Media and Nobel Webb – are accused of taking "many millions" of dollars from Swedish-American pharmaceutical giant AstraZeneca.
Read article here.

AstraZeneca's Crestor fails in new heart-failure study

AstraZeneca Plc's cholesterol drug Crestor has failed in a second clinical trial for heart failure, suggesting such statin medicines don't improve survival in patients with the chronic condition. Patients given Crestor proved just as likely to die early or be admitted to hospital with cardiovascular problems as those on standard therapy alone, researchers told the European Society of Cardiology annual meeting.
Read news report at reuters.com

Lose weight, reduce your risk of most cancers, high blood pressure, type 2 diabetes, stroke, heart disease, heart attack, vascular dementia, osteopenia, osteoporosis, hypercholesterolaemia, depression, liver and kidney problems, and improve your health in many other ways without drugs or expense by eating less salt! - Try it! - You will feel so much better!

And see Sodium in foods and

Associated health conditions

Free flights, meals and match tickets given to doctors by drug companies can damage patient care, say critics

Drug giants accused over doctors' perks
Article from the Guardian

Extracts:

"Drug companies are spending millions of pounds every year on all-expenses-paid trips to conferences around the world for doctors and other hospital staff, in what critics say is a massive marketing exercise dressed up as medical education.

The Guardian can reveal the scale of pharmaceutical company sponsorship following an examination of the registers of gifts and donations to doctors that all hospitals are required to keep. They show considerable largesse - from drug companies regularly picking up hefty bills for travel to international conferences in Europe, Asia and America, to specialist nurses' salaries, and weekly sandwich lunches for hospital staff training sessions.

All-expenses-paid trips to conferences in the US, Vietnam or Hungary are a regular feature of the registers, costing the companies up to £5,000 per doctor. Many of the declarations by doctors do not put a price on the trip. The total amounts received by staff at individual hospital trusts with complete registers are substantial - Sheffield's staff received funding of more than £105,000 from pharmaceutical and medical devices companies in the 12 months to last June.

Examples of the firms' hospitality include:

· Astra Zeneca paid £2,500 for a doctor at the Royal Bournemouth trust and £1,500 for a doctor at Sheffield teaching hospital to attend a cancer conference in Texas

· Sanofi-Aventis, the world's fourth biggest pharmaceutical company, paid for doctors at the Countess of Chester trust to go to conferences in Cape Town, New Orleans and Barcelona. At Gateshead trust, their reps gave a breakfast for 30 staff "to discuss drugs for the treatment of breast cancer". The trust's register records that "the donor was seeking to secure business".

· Roche spent £2,000 for an oncology consultant at Addenbrooke's hospital in Cambridge to go to a conference in May last year.

· GSK, the biggest British pharmaceutical company, paid £1,200 for a consultant at Sheffield teaching hospital to attend the 11th international congress of Parkinson's disease and movement disorders in Turkey last June."

"Joe Collier, the recently retired professor of medicines policy at St George's hospital, London, a former member of the Medicines Commission and an adviser to the select committee, said: "Through its orchestrated campaigns affecting all those involved in the use of medicines, the pharmaceutical industry enormously influences what patients are prescribed. On the whole these influences are detrimental to best practice."

Payments to doctors are far from transparent. The Department of Health requires NHS trusts to compile registers of their medical staff's and directors' possible conflicts of interest and to make them available to the public. Only a minority do so. The Guardian requested the registers for 90 hospital trusts under freedom of information legislation. Only around a quarter returned data that included the names of the doctors and the sponsoring companies and the amounts of money received. Some refused to give any information at all.

Collier said this was unacceptable. "Declarations of interest are a key way to help break the pharmaceutical industry's stranglehold. It is not a trivial issue. Public declarations by doctors are essential if prescribing is to be sensible and appropriate and according to patients' needs.""

"Labour MP Paul Flynn described as "codswallop" the companies' claim that their only intention was to help educate doctors. "It's not true. It's part of a huge marketing budget. It's all about maximising their profits, not helping people in life-threatening situations," he said. "The influence of these companies is enormous."

Doctors who receive funding believe they are not influenced by it. Robert Storey, a consultant cardiologist at Sheffield involved in drug trials, took four trips to conferences in the year to June 2007 courtesy of Astra Zeneca at a total cost of £12,000. However, he regards these as business trips because he is asked to disseminate research findings and are funded from the R&D budget. More junior doctors have their funding arranged through the drug rep and must fly economy class under Association of the British Pharmaceutical Industry (ABPI) rules.

"If it is done through the local rep, who may expect some sort of favour in exchange for that sponsorship, there is more stringent regulation," said Dr Storey. "[Those doctors] are seeing reps on a regular basis and although it is explicitly stated in the ABPI rules that there shouldn't be any conflict or conditions [on the funding], it probably does influence doctors' behaviour because they are unsure whether they will get further sponsorship for going to further meetings, so it is useful to them to engender good relationships with different reps."

I personally regard most of these expenses-paid junkets as bribery.