Pfizer fined for bribing foreign doctors and health care professionals

The US Securities and Exchange Commission has charged Pfizer with violating the Foreign Corrupt Practices Act after finding various subsidiaries bribed doctors and other health care professionals employed by foreign governments in order to win business.
Read article at pharmalot.com

Pfizer involved in deception over new arthritis painkiller drug Celebrex

"A research director for Pfizer was positively buoyant after reading that an important medical conference had just featured a study claiming that the new arthritis drug Celebrex was safer on the stomach than more established drugs. “They swallowed our story, hook, line and sinker,” he wrote in an e-mail to a colleague. The truth was that Celebrex was no better at protecting the stomach from serious complications than other drugs. It appeared that way only because Pfizer and its partner, Pharmacia, presented the results from the first six months of a yearlong study rather than the whole thing."
Read article in the New York Times (USA)

Really I don't think arthritis painkilling drugs are worth the candle. They've done a great deal of harm over the years. See my posts about Vioxx, for example.

You can reduce the pain of osteoarthritis by the simple expedient of seriously cutting down on salt and salty food. This dietary measure also lowers high blood pressure, reduces your risk of heart attack, stroke, depression, fractures, some cancers and many other degenerative illnesses, as well as reducing excess weight caused by fluid retention and helping with breathing problems. - What's not to like? - Try it! - You will feel so much better!

Pfizer: Prempro HRT Settlements costly

"Pfizer Inc. (PFE) (PFE), the world’s largest drugmaker (PFE), said in a securities filing that it has paid $896 million to resolve about 60 percent of the cases alleging its menopause drugs caused cancer in women. Pfizer has now settled about 6,000 lawsuits that claim Prempro and other hormone-replacement drugs caused breast cancer, and it has set aside an additional $330 million to resolve the remaining 4,000 suits, according to a filing with the U.S. Securities and Exchange Commission."
Read article at businessweek.com

See also http://en.wikipedia.org/wiki/Estrogen

Pfizer Research Scandal: FDA debars fraudster doctor, Scott Reuben

He was accused of faking research for a dozen years in published studies suggesting after-surgery benefits from Vioxx and Celebrex. Last year, he was sentenced to six months in jail plus three years supervised release after pleading guilty to fraud. The former chief of acute pain at Baystate Medical Center received grants from various drugmakers but never performed the studies, fabricated patient data and submitted info to journals that was unwittingly published. Now, the FDA has permanently debarring [sic] him from providing services in any capacity to a person that has an approved or pending drug product application, according to the debarment order, which was published today in The Federal Register.
Read article at pharmalot.com

Personally, I favour avoiding painkillers. - I've had two major operations and I refused painkillers for both of them. Yes, it hurts a lot when you come round from the anaesthetic, but you know the pain will gradually get less severe and you can steel yourself to cope with it. But with painkillers - especially the 'strong' ones - there are always adverse side-effects. And, as in this case, you cannot be sure that you have been given the facts about drugs. Drug companies indulge in criminality, including bribing key opinion leaders such as Scott Reuben was, to recommend their drugs, falsifying drug trial data, corrupting medical journals, etc. Painkiller drugs in particular seem to be problematic. The most recently publicised settlement for criminality of a drug company of which I am aware is the Merck/Vioxx scandal reported on the BBC News website last Tuesday. (Vioxx was a prescription painkiller.) Sadly, although Merck have had to pay almost $1bn (£640m) in settlement, this will not deter them from their criminal practices. That huge sum is insignificant in comparison to the colossal profits they garner from the sales of their dangerous products. Criminals, in my opinion - criminals whose crimes destroy the lives and health and happiness of millions of innocent people the world over - should be punished with the utmost rigour of the law, and that should, of course, mean imprisonment for the people at the top of the company, the people who instigate, fund and perpetuate the criminality.

At last some payouts for the first few victims out of the hundreds of Pfizer's Nigeria drug-trial victims

Read about it here. Why would Pfizer have chosen Africa for its drug trials, do you think? - I think we can make an educated guess. The legalities are easier. Possible victims would find it harder to seek compensation, even if they have managed to stay alive...

You could read John le Carré's novel The Constant Gardener or watch the excellent film of it, to learn rather more of the dark facts of African drug-trials. You may also find this blogpost of mine interesting. Sobering facts like these need to be borne in mind when new drugs are eagerly sought or welcomed. They come at a heavy cost, and it is not our cost.

Zyvox antibiotic and antidepressants together may prove fatal

Pfizer Inc.'s Zyvox antibiotic can cause potentially fatal central nervous system reactions in patients who also take antidepressants that increase levels of the brain chemical serotonin, U.S. regulators said.
Read article in the San Francisco Chronicle (USA)

Bribery of doctors and other NHS healthcare staff by pharmaceutical companies may be reduced by the Serious Fraud Office

An Independent on Sunday investigation has revealed that the bribery of doctors and other NHS healthcare staff with lavish hospitality and freebies by pharmaceutical companies may be reduced by the Serious Fraud Office.

"Big drug firms have spent millions of pounds on bankrolling events and trips for NHS staff, an Independent on Sunday investigation of trust records has revealed. The catalogue of freebies includes Pfizer providing hospitality to dozens of doctors attending a meeting at the five-star Gleneagles hotel resort in Scotland, and a dinner meeting between three Eli Lilly staff and two nurses at which 22 alcoholic drinks were consumed.

Healthcare staff, who influence how the £12bn annual NHS drugs budget is spent, insist they are not swayed by hospitality. However, it has emerged that big firms such as Sanofi-Aventis, Napp and Cephalon all feature in reports by the industry's watchdog, the Prescription Medicines Code of Practice Authority (PMCPA), into alleged breaches in the rules on hospitality."

I recommend reading the whole of this damning report, including the Comments beneath the report.

Pharmaceutical Industry's Criminal Fraud Settlements

Between 1991-2010, there were 165 criminal and/or civil settlements by major pharmaceutical companies comprising of $19.8 billion in penalties. Four of the world's largest drug companies--GlaxoSmithKline, Pfizer, Eli Lilly, and Schering-Plough--accounted for 53% ($10.5 billion) of penalties during these two decades.
Read article on the website of the Alliance for Human Research Protection (USA)

Slippery Statistics: there's something fishy about them!

I've been listening to Radio 4's More or Less programme first broadcast on Dec 31st 2010. If you go to this BBC webpage you too can listen to it using iPlayer. "Tim Harford and the More or Less team explore 2010 in numbers. Contributors include Ben Goldcare, Robert Peston, the National Statistician and the Swedish statistical guru Hans Rosling." - That should be Goldacre, btw, not Goldcare. It's a rare BBC typo...(o:

Anyway the programme includes Gordon Brown, when Prime Minister, being less than honest with statistics while speaking in the House of Commons. You will also hear of the wealth of misleading immigration figures that the British public was fed for years. And Robert Peston explains again about the crisis with the banks and their cash reserves. But the most important item in the programme in my opinion is the complaint by medical doctor and columnist, Ben Goldacre, that 74% of results of drug trials on Reboxetine, a so-called antidepressant drug manufactured by Pfizer, were not published in academic journals and were kept from doctors and patients. - Since the drug is "ineffective and worse than useless", but the actual published data claimed the opposite, Dr Goldacre describes this as "the greatest scandal of modern medicine."

You may, along with me, and along with Dr Goldacre, wonder why drug companies are allowed knowingly to mislead with fraudulent claims about their pharmaceutical junk, and why the medical journals are similarly allowed to skew the evidence by withholding trial results that show the drugs do more harm than good, and why nobody goes to prison for this fraud and for the harm that ensues to patients because of this fraud and for robbing the NHS purse and the British tax-payers by charging them for toxic trash. - The answer, as I'm sure you have worked out for yourself, is that Big Pharma's tainted profits make their way into the pockets of the venal.

Yes, Ladies and Gentlemen, follow the money: venal politicians, slick lawyers, publishers, share-dealers, drug reps, shady doctors, shady members of drug regulation panels, etc. Which of them join in the dance of of the dodgy drugs, and rake in their shares of the ill-gotten gains?

Pfizer and its calamitous drug trials in Nigeria.

Pfizer and its calamitous drug trials in Nigeria.- Justice delayed is justice denied. The Law should serve the afflicted, not the Pfizer pharmaceutical company that harmed them. Read this article and weep for the child victims of Big Pharma and its corrupt associates.

Misleading Drug Trial Claims made about Pfizer's antidepressant Reboxetine (Edronax)

See BBC News report. "Doctors and patients are being misled about the effectiveness of some drugs because negative trial results are not published, experts have warned.

Writing in the British Medical Journal, they say that pharmaceutical companies should be forced to publish all data, not just positive findings."

Pharmaceutical companies cannot be trusted. There is systematic manipulation and abuse of scholarly publishing by the pharmaceutical industry and its commercial partners in their attempt to influence the health care decisions of physicians and the general public.

See Public Library of Science webpage: http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1000156

Quite apart from the criticisms being published about these particular drug trials, it should be recognised that antidepressant drugs work no better than dummy pills anyway and should not be being prescribed. Most antidepressants make you fatter and damage your health in many other ways too, so it's best to avoid these harmful, useless drugs.

MIND, the mental health charity, recommends a walk in the country as being helpful in lifting depression.

Are you on a diet? - Dieting is an often overlooked, but significant cause of depression. Good nutrition is an excellent way to improve your health. Obviously when you are not eating enough for the needs of your body and your brain, you will experience both physical and mental harm. - It is not necessary (or desirable, or effective or even safe) to diet to lose weight. The safe, natural way to lose excess weight is to cut down on salt and salty food. Avoid ready meals and takeaways because these are usually highly salted and offer poor nutrition. They are likely to worsen your feelings of depression.

Good nutrition is the best doctor and the safest medicine.

US Department of Justice is probing corruption in the pharmaceutical industry

The US Department of Justice is scrutinising payments by leading pharmaceuticals companies for hospitality, consultants, licensing agreements and charitable donations in markets around the world as part of a wide-ranging corruption probe. GlaxoSmithKline, Pfizer, Bristol-Myers Squibb and Eli Lilly, among others, have disclosed being contacted by the DoJ and Securities and Exchange Commission in connection with the investigation. Merck, the US drugs group, announced that it had also been contacted and was co-operating with investigators.
Read article at yahoo.com

An investigation is long overdue, surely?

CNN Special Investigations Unit Highlights Pfizer Health Care Fraud re: Bextra Painkiller

See this damning report by CNN and this excellent article by Dr Mercola, about drug company corruption and manipulation of the FDA. I do urge you to read them and to remember that drug companies are not in business for your health, but for their wealth!

Good nutrition is the best physician and the safest medicine. For your health's sake, avoid taking prescription drugs unless they are really necessary.

The Canadian Medical Association is being criticized for agreeing to accept funding from Pfizer to create continuing medical education programs

The Canadian Medical Association is being criticized for agreeing to accept $78,000 in funding from Pfizer’s Canadian subsidiary to create continuing medical education programs.
Read article at pharmalot.com

Canada Reviews Pfizer Executive Appointment To Health Board

Canada’s Health Committee plans to review the controversial appointment of a Pfizer exec to the board of the Canadian Institutes of Health Research, the government agency that oversees health research in Canada, The Tyee reports. Bernard Prigent, Pfizer Canada’s medical director, was appointed last month to the CIHR’s governing council (see here). Last month, CIHR president Alain Beaudet said that he hopes to create closer ties with industry to ensure involvement and investment, but the move has stirred concerns since the organization is responsible for allocating research funding across the country, the paper writes. “There’s no place in our scientific organizations like CIHR for a drug company official,” NDP MP Judy Wasylycia-Leis, tells The Tyee. “It’s shocking that this government appointed the vice president of the biggest brand name drug company in the world, to the board of the CIHR which is supposed to be a body of independents and scientific endeavors free from any ties to industry at all.”
Read article at pharmalot.com

Record Fraud Fine for Pfizer

BBC News reports that "US drugmaker Pfizer has agreed to pay $2.3bn (£1.4bn) in the largest healthcare fraud settlement in the history of the Department of Justice."

As well as the criminal fraud, there were allegations of bribery to encourage healthcare providers to prescribe some of the company's drugs.

I reckon it's best to avoid pharmaceutical drugs if you can.

Good nutrition is the best physician and the safest medicine.

Widespread Misrepresentation of Drug Research Findings by Drug Companies Tarnishes Pharmaceutical Industry

Stuart Laidlow of the Toronto Star writes that "From the creation of fake academic journals, to bogus stories submitted to real journals, to falsified results in some of academia's most respected publications – the pharmaceutical industry has been rocked by allegations that the world's biggest drug companies put public relations above public safety."

Some of the drug companies involved include Merck, Eli Lilly and Pfizer.

Put not your trust in drug companies. They clearly care about their profits, rather than the health of the innocent people who get damaged by their products.

Champix - if you are interested in Champix, the drug that is prescribed to help smokers to kick the habit -

you may like to know there will be a programme about it on Radio 4 tomorrow evening, April 27 at 8pm, which will explore fears that the drug is linked to depression and even suicidal tendencies, and will question the manufacturer Pfizer about the drug's safety.

See http://www.bbc.co.uk/programmes/b00jwy34

Painkillers Double Risk of Second Heart Attack or Death in Study

Heart attack and heart failure patients have a higher risk of a second heart attack or death if they take painkillers including the generic drug ibuprofen and Pfizer Inc.'s Celebrex, a Danish study found. The risk doubled within the first 90 days on the painkillers Celebrex or Merck & Co.'s withdrawn Vioxx in those who had survived a heart attack or heart failure, compared with those who didn't take the medications, according to research presented today at the American Heart Association meeting in New Orleans. Other common painkillers, such as the generics diclofenac and ibuprofen, increased the risk between 2.1 and 1.3 times.
Read article at bloomberg.com

Chantix Tops New Report On Serious Side Effects

The number of serious problems and deaths linked to medications reported to the FDA set a record in the first three months of this year, the Institute for Safe Medication Practices reports. The FDA received nearly 21,000 reports of serious drug reactions, including over 4,800 deaths, according to ISMP’s an analysis of federal data dating to 2004. Yearly totals went back to the 1990s. Two drugs accounted for a disproportionately large share of the latest reports. One was heparin, the tainted blood thinner from China that caused an international safety scandal. The other was Chantix, a new kind of anti-smoking drug from Pfizer, which refuted the findings. The drug accounted for more reported serious injuries than any other prescription drug for a second quarter, a total of 1001 new cases, including 50 additional deaths. Earlier this year, the FDA warned that Chantix may be linked to psychiatric problems, including suicidal behavior and vivid dreams, and the government banned it for pilots.
Read article at pharmalot.com